Dexamethasone enhances glutamine synthetase activity and reduces N-methyl-D-aspartate neurotoxicity in mixed cultures of neurons and astrocytes
Astrocytes are claimed to protect neurons against excitotoxicity by clearing glutamate Hybrid Shorts from the extracellular space and rapidly converting it into glutamine.Glutamine, is then released into the extracellular medium, taken up by neurons and transformed back into glutamate which is then stored into synaptic vesicles.Glutamine synthetase